Discovering what’s already out there in the fight against COVID-19

Accencio® is currently applying our IP-GeoScape® technology and methods to biological targets including RNA polymerase inhibitors, viral protease inhibitors, and TLR7/8 antagonists to identify drugs that could be retargeted for use in COVID-19 patients.

Our work involves identifying any relationships between the molecular structures of existing advanced clinical or marketed molecules and molecules claimed to/believed to interact with these validated COVID-19 biological targets, with the hope we might be able to offer some new ideas for effective COVID-19 treatments. Our focus areas include tackling viral replication, viral invasion and the cytokine storm. To see the results for each target, click below:

Drug Drug name Original target
ubenimex Aminopeptidase inhibitor
roquinimex IL2 gene stimulator
UK-369082 Thrombin-active fibrinolysis inhibitor inhibitor
borofalan (10B)
imidazolyl ethanamide pentandioic acid
antineoplaston AS2-1 Glutamate receptor modulator
124I-TLX-101 L-type amino acid transporter 1 inhibitor
131I-TLX-101 L-type amino acid transporter 1 inhibitor
Sch-42495 Endopeptidase inhibitor
iofolastat I 123 Glutamate carboxypeptidase II inhibitor
laquinimod Aryl hydrocarbon receptor agonist
SC-49992 GP IIb IIIa antagonist
tasquinimod S100 calcium binding protein A9 modulator
nateglinide Calcium channel stimulator; Potassium channel inhibitor
nicousamide TGF-beta activated kinase-1 inhibitor
Drug Drug name Original target
remacemide NMDA receptor antagonist
Drug Drug name Original target
temanogrel 5-HT 2a receptor inverse agonist
Drug Drug name Original target
BIIB-021 Hsp 90 inhibitor
tenofovir Reverse transcriptase inhibitor
tenofovir exalidex Reverse transcriptase inhibitor
tenofovir disoproxil Reverse transcriptase inhibitor
Drug Drug name Original target

Want to find out more? Catch up on our latest retargeting webinar!

Catch up now

Information or suggestions to share?

If you have suggestions or ideas for new targets we could be exploring as part of our COVID-19 retargeting work, or you have biological screening information to share, please let us know here!

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