Discovering what’s already out there in the fight against COVID-19
Accencio® is currently applying our IP-GeoScape®
technology and methods to biological targets including RNA polymerase inhibitors, viral
protease inhibitors, and TLR7/8 antagonists to identify drugs that could be retargeted for
use in COVID-19 patients.
Our work involves identifying any relationships between the molecular structures of existing
advanced clinical or marketed molecules and molecules claimed to/believed to interact with
these validated COVID-19 biological targets, with the hope we might be able to offer some
new ideas for effective COVID-19 treatments. Our focus areas include tackling viral
replication, viral invasion and the cytokine storm. To see the results for each target,
click below:
Drug | Drug name | Original target |
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MR-708 | |
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ubenimex | Aminopeptidase inhibitor |
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roquinimex | IL2 gene stimulator |
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UK-369082 | Thrombin-active fibrinolysis inhibitor inhibitor |
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borofalan (10B) | |
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imidazolyl | ethanamide pentandioic acid |
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antineoplaston | AS2-1 Glutamate receptor modulator |
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124I-TLX-101 | L-type amino acid transporter 1 inhibitor |
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131I-TLX-101 | L-type amino acid transporter 1 inhibitor |
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Sch-42495 | Endopeptidase inhibitor |
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iofolastat | I 123 Glutamate carboxypeptidase II inhibitor |
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laquinimod | Aryl hydrocarbon receptor agonist |
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SC-49992 | GP IIb IIIa antagonist |
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tasquinimod | S100 calcium binding protein A9 modulator |
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acetylleucine | |
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nateglinide | Calcium channel stimulator; Potassium channel inhibitor |
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N,N`-diacetyl-L-cystine | |
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nicousamide | TGF-beta activated kinase-1 inhibitor |
Drug | Drug name | Original target |
---|---|---|
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remacemide | NMDA receptor antagonist |
Drug | Drug name | Original target |
---|---|---|
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temanogrel | 5-HT 2a receptor inverse agonist |
Drug | Drug name | Original target |
---|---|---|
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epetirimod | |
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BIIB-021 | Hsp 90 inhibitor |
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tenofovir | Reverse transcriptase inhibitor |
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tenofovir exalidex | Reverse transcriptase inhibitor |
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tenofovir disoproxil | Reverse transcriptase inhibitor |
Drug | Drug name | Original target |
---|---|---|
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RG-7166 |