Discovering what’s already out there in the fight against COVID-19

Accencio® is currently applying our IP-GeoScape® technology and methods to biological targets including RNA polymerase inhibitors, viral protease inhibitors, and TLR7/8 antagonists to identify drugs that could be retargeted for use in COVID-19 patients.

Our work involves identifying any relationships between the molecular structures of existing advanced clinical or marketed molecules and molecules claimed to/believed to interact with these validated COVID-19 biological targets, with the hope we might be able to offer some new ideas for effective COVID-19 treatments. Our focus areas include tackling viral replication, viral invasion and the cytokine storm. To see the results for each target, click below:

Drug
Drug name
Original target
DFP-10917, TAS-109
gemcitabine
Adenogesic
Adenosine A1 receptor agonist; Adenosine A2 receptor agonist
nucleoside analogs (iv, cancer), MD Anderson Cancer Center
RNA polymerase inhibitor
ethynylcytidine
DNA RNA polymerase III inhibitor
OVI-123
MBC-11
clofarabine
DNA polymerase inhibitor; Ribonucleotide reductase inhibitor,
adenosine triphosphate
Adenosine receptor agonist
fludarabine
DNA polymerase alpha inhibitor; DNA primase inhibitor;Ribonucleotide reductase inhibitor
cladribine
Adenosine deaminase inhibitor
2-CdAP
nelarabine
5-Fluoro -2 -deoxycytidine
Methyltransferase inhibitor
YT-146
Adenosine A2 receptor agonist
NB-1011
Thymidylate synthase inhibitor
citicoline
aspacytarabine
LY-2334737
doxifluridine
Thymidylate synthase inhibitor
tocladesine
uridine triacetate
sapacitabine
DNA polymerase inhibitor
ropidoxuridine
Nu-3
ARL-67085
Adenosine receptor antagonist; P2Y12 purinoceptor antagonist
bucladesine
Cyclic nucleotide modulator
capecitabine
Thymidylate synthase inhibitor
SHP-622
Amyloid protein deposition inhibitor; Beta amyloid antagonist
etodolac
Cyclooxygenase 2 inhibitor; Oxidoreductase inhibitor
gemcitabine elaidate
fosfluridine tidoxil
Thymidylate synthase inhibitor
ademetionine
Transferase stimulator
indoximod
Indoleamine-pyrrole-2,3-dioxygenase inhibitor
tezacitabine
Ribonucleotide reductase inhibitor
POL-240
NUC-7738
fosifloxuridine nafalbenamide
tegafur 
nitazoxanide
Stellate protein kinase inhibitor; Tyrosine kinase receptor modulator
loxoribine
DMDC
rociletinib
EGFR family tyrosine kinase receptor inhibitor
fosgemcitabine palabenamide
OGT-719
R-phenylisopropyladenosine
Adenosine A1 receptor agonist
melatonin
Melatonin receptor agonist
oxitriptan
acetylsalicylic acid
Cyclooxygenase inhibitor
GR-79236
Adenosine A1 receptor agonist
velaresol
SDZ-WAG-994
Adenosine A1 receptor agonist
triflusal
Nuclear factor kappa B modulator
piclidenoson
Adenosine A3 receptor agonist
UR-1505
dl-PHPB
tecadenoson
Adenosine A1 receptor agonist
zaleplon
Benzodiazepine receptor agonist
selodenoson
Adenosine A1 receptor agonist
zidovudine
Nucleoside reverse transcriptase inhibitor
ZSP-1273
DNA RNA polymerase inhibitor
Drug
Drug name
Original target
ubenimex
Aminopeptidase inhibitor
SM-8849
entacapone
Catechol O-methyltransferase inhibitor
frovatriptan
5-HT 1b receptor agonist; 5-HT 1d receptor agonist
warfarin
Factor IIa antagonist
VTP-27999
Renin inhibitor
trofinetide
Cytokine receptor antagonist
MSI-469
GPI-1485
FK506 binding protein modulator
4-PBA
Histone deacetylase inhibitor
MR-708
thymocartin
ibuprofen lysine
Cyclooxygenase inhibitor
darinaparsin
E-5050
glutathione
Nuclear factor kappa B inhibitor
PBI-4050
Connective tissue growth factor ligand inhibitor
lacosamide
Dihydropyrimidinase related protein 2 modulator; Sodium channel modulator
lisdexamfetamine
sodium phenylbutyrate
Histone deacetylase inhibitor
enalapril maleate
ACE inhibitor
Thymotrinan
antineoplaston
AS2-1 Glutamate receptor modulator
Sch-42495
Endopeptidase inhibitor
dl-PHPB
SC-49992
GP IIb IIIa antagonist
PZ-128
Protease-activated receptor-1 antagonist
lisinopril
ACE inhibitor
N30-201
Alcohol dehydrogenase 5 modulator
esmolol
Beta adrenoceptor antagonist
iofolastat
I 123 Glutamate carboxypeptidase II inhibitor
atenolol
Beta 1 adrenoceptor antagonist, Beta 2 adrenoceptor antagonist
PL-37
Aminopeptidase N inhibitor; Neutral endopeptidase inhibitor
L-653328
Beta adrenoceptor antagonist
dexamfetamine prodrug
Adrenergic receptor agonist
esprolol
Beta adrenoceptor antagonist
CCR1 antagonists (rheumatoid arthritis), Bristol-Myers Squibb CCR1 chemokine antagonist
terameprocol
Survivin protein inhibitor
metoprolol
Adrenergic receptor antagonist
Allotrap-2702
perindopril
ACE inhibitor
sobetirome
Thyroid hormone receptor beta agonist
trandolapril
ACE inhibitor
bisoprolol
Beta adrenoceptor antagonist
NO-antihypertensives, NicOx/Merck & Co ACE inhibitor
masoprocol
Erbb2 tyrosine kinase receptor inhibitor; Insulin-like growth factor 1 receptor antagonist; Lipase inhibitor
ramipril
ACE inhibitor
ONO-4057
Leukotriene BLT receptor antagonist
Hoe-065
Acetylcholine receptor agonist; Acetylcholinesterase inhibitor
anipamil
Calcium channel inhibitor
verapamil
Calcium channel inhibitor
ACT-519276
Glucosylceramide synthase inhibitor
celiprolol
Beta adrenoceptor antagonist
lucerastat
Glucosylceramide synthase inhibitor
felbinac
Cyclooxygenase inhibitor
nitecapone
Catechol O-methyltransferase inhibitor
cyclizine lactate
Histamine H1 receptor antagonist
NPC-15199
quinapril
ACE inhibitor
COX-2 inhibitors (2), Almirall
Cyclooxygenase 2 inhibitor
Drug
Drug name
Original target
MR-708
ubenimex
Aminopeptidase inhibitor
roquinimex
IL2 gene stimulator
UK-369082
Thrombin-active fibrinolysis inhibitor inhibitor
borofalan (10B)
imidazolyl
ethanamide pentandioic acid
antineoplaston
AS2-1 Glutamate receptor modulator
124I-TLX-101
L-type amino acid transporter 1 inhibitor
131I-TLX-101
L-type amino acid transporter 1 inhibitor
Sch-42495
Endopeptidase inhibitor
iofolastat
I 123 Glutamate carboxypeptidase II inhibitor
laquinimod
Aryl hydrocarbon receptor agonist
SC-49992
GP IIb IIIa antagonist
tasquinimod
S100 calcium binding protein A9 modulator
acetylleucine
nateglinide
Calcium channel stimulator; Potassium channel inhibitor
N,N`-diacetyl-L-cystine
nicousamide
TGF-beta activated kinase-1 inhibitor
Drug
Drug name
Original target
remacemide
NMDA receptor antagonist
Drug
Drug name
Original target
temanogrel
5-HT 2a receptor inverse agonist
Drug
Drug name
Original target
epetirimod
BIIB-021
Hsp 90 inhibitor
tenofovir
Reverse transcriptase inhibitor
tenofovir exalidex
Reverse transcriptase inhibitor
tenofovir disoproxil
Reverse transcriptase inhibitor
Drug
Drug name
Original target
RG-7166


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Information or suggestions to share?

If you have suggestions or ideas for new targets we could be exploring as part of our COVID-19 retargeting work, or you have biological screening information to share, please let us know here!















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