Discovering what’s already out there in the fight against COVID-19

Accencio® is currently applying our IP-GeoScape® technology and methods to biological targets including RNA polymerase inhibitors, viral protease inhibitors, and TLR7/8 antagonists to identify drugs that could be retargeted for use in COVID-19 patients.

Our work involves identifying any relationships between the molecular structures of existing advanced clinical or marketed molecules and molecules claimed to/believed to interact with these validated COVID-19 biological targets, with the hope we might be able to offer some new ideas for effective COVID-19 treatments. Our focus areas include tackling viral replication, viral invasion and the cytokine storm. To see the results for each target, click below:

Drug Drug name Original target
MR-708
ubenimex Aminopeptidase inhibitor
roquinimex IL2 gene stimulator
UK-369082 Thrombin-active fibrinolysis inhibitor inhibitor
borofalan (10B)
imidazolyl ethanamide pentandioic acid
antineoplaston AS2-1 Glutamate receptor modulator
124I-TLX-101 L-type amino acid transporter 1 inhibitor
131I-TLX-101 L-type amino acid transporter 1 inhibitor
Sch-42495 Endopeptidase inhibitor
iofolastat I 123 Glutamate carboxypeptidase II inhibitor
laquinimod Aryl hydrocarbon receptor agonist
SC-49992 GP IIb IIIa antagonist
tasquinimod S100 calcium binding protein A9 modulator
acetylleucine
nateglinide Calcium channel stimulator; Potassium channel inhibitor
N,N`-diacetyl-L-cystine
nicousamide TGF-beta activated kinase-1 inhibitor
Drug Drug name Original target
remacemide NMDA receptor antagonist
Drug Drug name Original target
temanogrel 5-HT 2a receptor inverse agonist
Drug Drug name Original target
epetirimod
BIIB-021 Hsp 90 inhibitor
tenofovir Reverse transcriptase inhibitor
tenofovir exalidex Reverse transcriptase inhibitor
tenofovir disoproxil Reverse transcriptase inhibitor
Drug Drug name Original target
RG-7166


Want to find out more? Catch up on our latest retargeting webinar!



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Information or suggestions to share?

If you have suggestions or ideas for new targets we could be exploring as part of our COVID-19 retargeting work, or you have biological screening information to share, please let us know here!















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